cycle in developing embryos A Schematic of early Biology Diagrams Understanding the mechanisms of embryonic cell cycles is a central goal of developmental biology, as the regulation of the cell cycle must be closely coordinated with other events during early embryogenesis. Quantitative imaging approaches have recently begun to reveal how the cell cycle oscillator โฆ Summary: This Review discusses emerging quantitative principles for how embryos coordinate cell cycle timing and morphogenesis. Introduction. In many species, early development initiates with rapid and almost synchronous mitotic divisions that slow over time as the embryo approaches the key developmental transition to gastrulation (Foe et al., 1993; O'Farrell, 2015).
Early embryonic development is characterized by a plethora of very complex and simultaneously operating processes, which are constantly changing cellular morphology and behaviour. Regulation of the cell cycle in early mammalian embryos and its clinical implications Int J Dev Biol. 2019;63(3-4-5):113-122. doi: 10.1387/ijdb.180400ma. The role of the cell cycle as an inhibitor of the late stages of cellular differentiation is well known, but in early embryonic development its role is mysterious. Normally, embryonic stem (ES) cells proliferate quickly during differentiation and do
Human embryonic development Biology Diagrams
1. Introduction. Animal embryonic development is well-orchestrated in time and in space. Being composed of manifold diverse cellular and biochemical events, developmental transitions such as oocyte-to-embryo transition and maternal-to-zygotic transition are regulated by multiple, sometimes independent signals [1,2,3], which add up to precise and robust spatiotemporal regulation. Proper control of embryonic development requires that the correct number of cells assume the right fate and position. At the heart of such process are mechanisms controlling cell proliferation and positioning. Recent advancements in imaging and computational methods have begun to reveal how the cell cycle is controlled during development and The preimplantation development stage of mammalian embryogenesis consists of a series of highly conserved, regulated, and predictable cell divisions. This process is essential to allow the rapid expansion and differentiation of a single-cell zygote into a multicellular blastocyst containing cells of โฆ
This could be achieved by combining studies on in vitro cultured human embryos (Xiang et al., 2019) with in vivo and in vitro cultured monkey embryos (Nakamura et al., 2016; Niu et al., 2019; Ma et al., 2019) and the development of new stem cell models of the human embryo comprising both embryonic and extra-embryonic stem cells, as previously
Regulation of the cell cycle in early mammalian embryos and its ... Biology Diagrams
Elaboration of a multicellular organism requires highly efficient coordination between proliferation and developmental processes. Accordingly, the embryonic cell cycle exhibits a high degree of plasticity; however, the mechanisms underlying its regulation in vivo remain largely unknown. The purpose of this review is to summarize the data on cell cycle regulation during the early mouse
