Regulatory Mechanisms of MitogenActivated Biology Diagrams In this review, we discuss the emerging roles of PPPs in mitosis and their regulation of and by mitotic kinases, as well as mechanisms that determine PPP substrate recognition and specificity. Keywords: phosphatases, kinases The relative activities of major mitotic protein kinases including Cdk1, AURKA, AURKB, and Plk1, indicated in blue Considering that CDK1 has hundreds of substrates and that several other protein kinases, such as Aurora A and B, Polo, Wee1 and Myt1 are involved in entry into mitosis and mitotic progression, several different protein phosphatases are probably involved in the reversal or regulation of these processes (Table 1). A number of protein kinases and checkpoint phosphoproteins are required for the function of the spindle assembly checkpoint. This review discusses the recent progress in understanding the role of protein kinases of the mitotic checkpoint complex in the surveillance pathway of the checkpoint.
Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones.
Protein phosphatases in the regulation of mitosis Biology Diagrams
Mitotic kinases are major regulators of protein function, but equally important are protein phosphatases that balance their actions, their coordinated activity being essential for accurate chromosome segregation. 2007. Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J. Biol. Chem. 282:28874-28883. 10.1074/jbc
Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division. In reality, the human Background: The mitotic DNA integrity checkpoint signaling pathway is potentially involved in cancers that regulate genomic stability where protein kinases play a pivotal role. 16 total protein kinase genes are involved in this pathway: ATM, BRSK1, CDK1, CDK2, CHEK1, CHEK2, MAP3K20, NEK11, PLK1, PLK2, PLK3, PRKDC, STK33, TAOK1, TAOK2, and TAOK3. This study aims to provide pan-cancer profiles Finally, to further investigate the temporal dynamics of phosphorylation regulation during cell cycle progression, we predicted the specific protein kinases responsible for CCD phosphorylation events.
